Alzheimer's Disease ,Chinese and Western Cognition and Therapy
Alzheimer's disease (AD)is a common neurodegenerative disease in the elderly, the current mainstream medicine (Western medicine) that the main pathological features areβ-amyloid protein (Aβ) aggregates into senile plaques,cells to form neurofibrillary tangles(NFT) andneuronal death, etc., with progressive cognitive impairment and memory decline as the main clinical symptoms. Domestic commonly referred to as senile dementia, also known as senile dementia, Alzheimer's disease is the most common case of senile dementia.
in the world, every3 seconds, there will be an additional case of Alzheimer's disease. Over 65 years old, the probability of illness is 5%; For 80-year-olds, the prevalence rate rises to 10%.the age of 90, the incidence rate has reached an astonishing 50%.. This means that at the age of 100, more than half of the people have to face the problem of Alzheimer's disease.
currently, Alzheimer's,there are no very effective treatment options, over the past three decades, the total number of drugs that have been invented to treat Alzheimer's,is 0.
symptoms of Alzheimer's disease
(1-3 years) is early dementia
performance is memory loss; decreased ability to judge, unable to analyze and think,difficult to deal with complexproblems; difficulty in distinguishing between distance and color; apathy and social difficulties; impairment in judging time and space; increased anxiety.
second stage (2-10 years) is middle stage dementia
is characterized by severe memory impairment, language difficulties, inability to carry out outdoor activities independently, and need help in dressing and personal hygiene;
inability to learn new tasks or respond to unexpected situations; inability to control themselves, such as undressing in inappropriate locations, or using vulgar language; deterioration of behavior, such as irritability, tears, frequent walking, especially in the evening.
Stage III (Years 8-12) for Advanced Dementia
patients have been completely dependent on care givers, severe memory loss, unable to communicate, and know relatives; unable to take care of themselves in daily life, incontinence; often sleep, moaning and purring; eventually coma, generally died of complications such as infection.
occasional loss of memory is a sign of normal aging. However, if it is accompanied by other symptoms, such as a sharp decline in language ability, a large number of memory loss or errors, it is best to go to the hospital for examination.
pathological hypothesis(from online article)
According to scientific imaging molecular biology, the current public is more recognized.reason hypothesishave two:β-amyloid precipitation,insulin resistance.
1, beta amyloid protein precipitation
to put it simply, they are some wrong proteins, which will "squeeze" brain cells when they gather in the brain, shrink the brain, degrade brain function, and cause patients to have more serious cognitive impairment.
A comparative study published in the New England Journal of Medicine in 2012 found that the process of Alzheimer's disease began 20 years before the onset of the disease. In summary, our findings indicate that theAlzheimer's disease process begins more than 20 years before the clinicalonset of dementia.
studies have found that in the early stages of Alzheimer's disease, neurofibrillary tangles and senile plaques are produced before the pathological featuresoxidative stress.
in response to oxidative stress, amyloid beta precipitation as the first stage of disease developmentcompensatory reaction.
that is to say, beta amyloid protein precipitation is "good intentions do bad things.
originally a good person, because of oxidative stress, the body's self-protection, beta amyloid deposits will appear in the brain, and eventually form more serious neurofibrillary tangles.
2, insulin resistance, the harm of rice sugar
many people know that the main cause of diabetes is insulin resistance,eating too much rice sugar may lead to diabetes and may also accelerate Alzheimer's disease.
Alzheimer's disease, also knownType 3 diabetes mellitus, more and more studies have found that it is inseparable from insulin resistance.
studies have found that in early Alzheimer's disease, decreased glucose metabolism and impaired energy metabolism of nerve cells may be relatedinsulin signaling pathwayrelated.
insulin signal disorder, will inevitably lead to cognitive dysfunction. Insulin is not only an important hormone to regulate blood glucose and energy metabolism, but also a neurotrophic factor, which is involved in cell survival, learning and memory formation, and inhibits apoptosis.
insulin resistance, can cause abnormal glucose metabolism in the brain.
, more and more studies have found that Alzheimer's disease and type 2 diabetes both have abnormal glucose metabolism, and this abnormal metabolism can damage the human brain.
researchers at the National Institute on Aging (NIA) tried to find answers from the bodies of Alzheimer's patients.
researchers divided the brain tissue samples of the participants into three groups: group 1: obvious Alzheimer's symptoms, tangles and amyloid plaques in the brain, group 2: no obvious symptoms, but tangles and plaques in the brain, group 3: no Alzheimer's disease
found that, compared with the normal brain,Decreased activities of certain enzymes that control the metabolism of glucose, and decreased levels of the glucose transporter GLUT3.
cereals, is also thought to be a cause of Alzheimer's, and it can leadinflammation, greatly increases the risk of dementia.
this means that the brain's ability to metabolize glucose is reduced, which may be related to the occurrence and development of Alzheimer's disease.
Western medicine treatment and drugs(from online article)
Current Western medicine is based on its hypothesis for drug development, as well as phenomenon-targeted emotional interventions, including anti-anxiety drug,antidepressants and antipsychotics, as well as a combination of Chinese and Western drugs in the use of nootropics. At present, the development of many neurodegenerative diseases treatment methods have failed, and many pharmaceutical companies around the world have invested in Alzheimer's disease treatment drugs,but beta-amyloid research is out of the clinical trial chain., as in 2012,Pfizer,Johnson & Johnsonet al. announced the cessation of research and development of Alzheimer's drug Bapinuezumab; in June 2018,Lillyannounces that it and AstraZeneca are discontinuing oral beta secretaselyase(BACE) inhibitors Lanabecestat for Alzheimer's disease.
TCM about Alzheimer's disease and treatment (author's opinion)
Alzheimer's disease is a Western medical term. In Chinese medicine, it is classified as a disease of the mind, which also includes diseases of all ages with various yin and yang symptoms, such as epilepsy the yin disease yang syptoms, depression the yin disease yin syptoms, mania the yang disease yang symptoms, dementia the yang deficiency syndrome. aged degenerative dementia and childhood developmental congenital deficiencies of the five late and five soft developmental delays of dementia are due to the emptying of the medulla, only also the direction of physiological development in old age and young age is opposite, but the symptoms are the same on the basis of the same medulla level, that is why there is the Chinese saying, senior behavior as a child, expressing the similarity of their emotional and cognitive behavior levels. The elderly, as a normal regression, the divine consciousness is chaotic, so that there is no other and no self, gradualy to die, that is one of the five blessings spoken by the ancestors. But if there is a mismatch with the function of the limbs and viscera,the medulla oblongata accelerates the degeneration of the void, it is a disease. Western medicine's microscopic findings of abnormal amyloid plaques or neural tangles in the brain and the atrophy of normal brain marrow in the image map can corroborate the theoretical understanding of the medulla oblongata in Chinese medicine. Only the respective therapies of Western and Chinese medicine differ. Western medicine tries to block and improve the process of alienation through molecular drugs, using the discovered subject as a means of breakthrough, such as the study of TAU amyloid control, etc., but TCM through is to support the positive and evil to go away from itself as a means and method. Therefore, TCM will take the direction of filling the marrow, strengthening the brain and educating the mind. Combined with the six arts of Chinese medicine each characteristic presents a different therapy.
1. Qigong Guided Exercise Method, Key Words, Yun
Health Qigong Baduanjin, Wuqinxi, Taijiquan, ZhanZui, meditation and other exercises that regulate the soul and relax the body by breathing and guide the qi and blood can strengthen the microcirculation of the whole body and ensure the support of the whole body, especially the brain. ZhouTian kongfu in Taoism exercises can strengthen the kidney qi, which is the sea of medullary, just supplementing the supply of the brain. in additon to the benefits of these traditional internal functions for the forging of the organs and limbs.
2. Acupuncture and moxibustion: key words,meridians, meridians can adjust all kinds of diseases to decide life and death. The role of acupuncture in the regulation of mental encephalopathy often transcends modern medical cognition. Xingnao Kaiqiao(brain waking) acupuncture and emergency acupuncture have magical effects on awakening brain consciousness. Whether it is stroke, epilepsy, autism or dementia, clinical applications have significant effects.
3. Chinese medicine recuperation: key words, recuperation. Traditional Chinese medicine believes that people are the trinity of essence, qi and spirit, and qi can change spirit. At the material level, Western medicine has observed the degeneration of the medulla in the brain, the death of normal cells and the accumulation of abnormal proteins. This is exactly the reverse process of refining and gasifying Qi to spirit(mind) in traditional Chinese medicine, which is called retrogression in western medicine. However, what is used in Chinese medicine or traditional practice 1 is the method of positively refining and gasifying Qi to spirit. It's just unbelievable by some people who believe in technology science. Fortunately, there is a saying in traditional Chinese medicine called the believer's spirit. Traditional culture will not force others to believe in anything, so it is often used to interpret people's understanding level and acceptance relationship. However, the focus of this article 3 is not on Gasifying Qi to spirit, but on the material basis , the essence and the Qi. It is the metaphysical level. At the metaphysical level, Chinese medicine regulates and provides for the needs of all parts of the body according to the taste and function of material. Therefore, all kinds of medicine prescriptions of traditional Chinese medicine that fill the marrow, increase the mind and awaken the mind have a very active effect on the improvement of brain function and mind.
4. Mind Regulation, Key words: Love and do.
Since retirement or their children's careered, many elderly people have no worries about food and clothing, no labor, no exercise, and no activities. Many people live a very lonely life, seldom communicate with each other, and their brains seldom work. As a result of using them, their brains become rusty and degenerate. Therefore, old friends should always have good, fun, love, do some self-activation or public welfare activities, and integrate themselves into the living society. Having fun is meaningful. Playing majiang (not sedentary ), the brain will not rust.
4.mental adjusting
in the view of traditional Chinese medicine, many human diseases originate from living habits and mental nature. exercising, can strengthen and invigorate blood and qi circulation. kindness can tolerent people and gives love. And love is high-frequency energy, If Love is in heart and want to help others, the hot new blood will born, and the brain will not degenerate. The body is a very intelligent program. Where energy is used more, where will be delivered more .
